Researchers at the University of Illinois Urbana-Champaign have developed a groundbreaking nanorobot called the NanoGripper, a DNA-based device that can detect and combat viruses with remarkable precision.
This innovative “hand,” folded entirely from a single strand of DNA, offers a new approach to virus detection, diagnostics, and targeted drug delivery.The research, led by Xing Wang, professor of bioengineering and chemistry, is published in Science Robotics.NanoGripper: Inspired by Nature, Powered by DNAThe NanoGripper is designed to mimic the gripping abilities of human hands and bird claws. With four bendable fingers and a palm, it is built from a single DNA strand using advanced origami techniques.
Each finger has three joints, allowing controlled bending angles for precise movement.DNA was chosen as the building material due to its strength, flexibility, and programmability. “We wanted to create a nanoscale robot with unique grabbing functions to interact with cells, viruses, and molecules for biomedical applications,” said Wang.The NanoGripper’s innovative design folds a long DNA strand back and forth to form both static and moving parts in a single step.
Advanced Virus Detection and BlockageThe NanoGripper’s fingers are equipped with DNA aptamers programmed to target specific molecules, such as the spike protein of the virus causing COVID-19. These aptamers trigger the fingers to bend and wrap around the target.On the opposite side, the “wrist” can attach to surfaces or larger complexes, enabling applications such as:Virus detection: The NanoGripper was paired with a photonic crystal sensor platform, developed by Professor Brian Cunningham, to create a rapid COVID-19 test. This 30-minute test matches the sensitivity of qPCR tests used in hospitals, offering faster and more convenient diagnostics.Blocking viral entry: By binding to the virus, the NanoGripper can prevent it from entering cells, potentially halting infection.
Expanding Applications Beyond COVID-19The versatility of the NanoGripper allows it to be programmed for other biomedical tasks, such as recognizing cancer cell markers for targeted drug delivery. Its modular design opens the door for new diagnostic tools, therapeutic interventions, and biosensing applications.”Our innovation has potential far beyond virus detection,” Wang stated. “This could redefine how we approach drug delivery and disease diagnostics in the future.
“The Future of DNA NanoroboticsThe NanoGripper demonstrates the immense potential of DNA nanotechnology in medicine. Its ability to rapidly detect and neutralize pathogens, combined with its programmability, marks a significant step forward in nanorobotics for healthcare.Meta Description: Discover the revolutionary NanoGripper, a DNA-based nanorobot designed for virus detection, diagnostics, and targeted drug delivery, with potential applications in cancer treatment .
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